I’ve been legally blind my whole life. There are definitely some big limitations, like not being able to drive. But I live in an apartment where I can walk to work. I can use a computer with an arm to bring the monitor closer and use a screen magnifier. I can look at things far away with a monocular or through my phone camera. Basically you might have to find innovative ways of doing things, but there’s usually a workaround. It can even be fun to think of clever solutions.
While I think LibreOffice is great and definitely fills the needs for most people, I wish it was more polished. IMO MS Office just feels so smooth and clean, whereas LibreOffice feels clunky and dated. And I miss Excel when using Calc, although it gets the job done.