Dxvk is usually better, but using vulkan is the better strategic move, you’ll increase their vulkan stats and provide QA. Good native vulkan support will beat dxvk every time.
Gaming on linux is a decades old ongoing effort, there’s plenty of praise to go around, vulkan and winehq, dxvk…
As a fix, you can run the game through gamescope which should sandbox the game.
Wine can run 32 bit games with WOW64 without the 32 bit libraries