May I ask what dosage you’re taking? I started at 1200mg twice a day for awhile, but ran out and about a week later noticed a worsening of my tics/hand-talking/dropping things issues. Started 1800mg (3x600mg taken morning/afternoon/night) once I bought more, but saw dosages of 2000-2400mg in a study or two.
I looked back through my NIH history and you’re right about the sparse evidence for ADHD, actually. Looks like my interest in NAC, in addition to weaning off THC, came from the bipolar and autism angle, its ability to act a a lead chelator, as well as some tentative dots I connected between its glutamatergic effects and some reading into a mutation of the MC1R gene as passed down to me by my red-head mother.
Likely also conflated my more recent readings into the guanfacine+NAC combo for my brain fog and sleep issues and misremembered my findings from the initial research. Good catch, and an excellent example of ‘don’t listen to the internet dude.’
Here are some starting points
NAC https://pmc.ncbi.nlm.nih.gov/articles/PMC8211525 - NAC review
https://www.sciencedirect.com/science/article/pii/S0149763415001190
https://pubmed.ncbi.nlm.nih.gov/35316513/
NAC+Guanfacine https://pmc.ncbi.nlm.nih.gov/articles/PMC10960163
Big props for the PubMed link, hard to take anything else seriously.
NAC - N-acetyl-cysteine. Psychiatrist recommended it for weaning myself off a THC dependency, but after reading a few PubMed-available research papers I found data supporting further research into its effects on ADHD.
Additionally, I kept researching in an attempt to improve brain fog and sleep issues I suspect are from long COVID. I found studies indicating NAC combined with guanfacine may help those symptoms.
I’ve found better results from 600mg NAC (standard daily dose is 1200mg) taken three times a day, and started 1mg guanfacine twice a day recently with plans to increase to 2mg twice a day in a week or two.
I would love to share the NIH papers with anyone interested. Educating yourself about your condition and its particular manifestation will get you far with an invested care team. I’m headed to bed bit will reply to any and every person interested in the research tomorrow morning.
The message I sent to my psych two days after she recommended NAC contained inline citations referring to the papers I had linked at the bottom. That due diligence communicated my dedication not only to my own care, but also to my dedication and respect for knowledge.
Don’t take random supplements recommended to you on the internet. Discuss their use with a doctor or, barring that, ground your decisions in science.
As someone who was just diagnosed with C5-C6 spondylosis and facet arthritis, with an MRI ordered to see how absolutely fucked my trapezius is; thank you for reinforcing what I’ve already told every doctor since my ex-fiance’s little brother overdosed and died:
Fuck opiates.
Everything else you mentioned was informative or reinforced my doctors advice, I appreciate it.
May I introduce you to prog?
Covet and CHON are a good place to start for instrumental math rock; I reccomennd effloresce and Homey, respectively.
From there I’d suggest Plini, Intervals, and Arch Echo to add some grit.
But if you really really want to hate yourself and break your guitar over you knee? Id like to introduce you to Tosin Abasi;
Over 5 months of near weekly appointments, I’ve managed to show up early twice.
How early? About 24 hours. Late to everything else all the time. Granted this is the best quality of care I’ve ever experienced and don’t want to fuck it up. Turns out that’ll motivate me!
You’re absolutely right. Ive seen a few mentions of research into phase changing materials for heat transfer, but I think the technology is still in its infancy. Would be cool to see a static PCM heat exchanger. Might be possible to leverage sun exposure/shading for more favorable ∆T? Been a bit since senior Heat Transfer.
and their kids don’t get to go to school anymore.
This part is actually a feature. You think desperate farmers are going to let crops rot in the field while their kids attend school? And that’s just family farms! Just wait until the inner city high schools start getting tapped for factory farms!
Not only is 88 considered auspicious in his native culture, he was also born in 1988. Normally, yes, be wary of the 88 dog whistle, but without further evidence it looks like a nothing-burger in this case.
NAC without guanfacine improved several of my hyperactive symptoms and the other poster’s skin picking if you’d like to mention that in the post.
Also, I think it’s chelating effect on lead and other heavy metals in the bloodstream is valuable on it’s own since we’re still using leaded AVgas and such. Leaded gasoline is why engineers need history classes; the Romans showed us how great ingesting lead is, and then 2000 years we decide aerosolizing it sounded like a good idea‽